MLH3 gene homepage

General information
Gene symbol MLH3
Gene name mutL homolog 3
Chromosome 14
Chromosomal band q24.3
Imprinted Unknown
Genomic reference LRG_217
Transcript reference NM_001040108.1
Associated with diseases ?, AML, cancer, gastric, CRC, Lynch Syndrome, MINAS, MRTES, polyposis, polyps, adenoma, cancer, cancer, bladder, cancer, brain, cancer, breast, cancer, endometrial, cancer, ovarian, cancer, pancreatic, cancer, rectal, cancer, skin, squamous cell carcinoma, Esophageal cancer, glioma, malignant, in silico,
Citation reference(s) -
Curators (1) John Paul Plazzer
Total number of public variants reported 286
Unique public DNA variants reported 76
Individuals with public variants 287
Hidden variants 0
Date created January 27, 2016
Date last updated April 03, 2018
Version MLH3:180403

Graphical displays and utilities
Graphs Graphs displaying summary information of all variants in the database »
UCSC Genome Browser Show variants in the UCSC Genome Browser (full view, compact view)
Ensembl Genome Browser Show variants in the Ensembl Genome Browser (full view, compact view)
NCBI Sequence Viewer Show distribution histogram of variants in the NCBI Sequence Viewer

Links to other resources
HGNC 7128
Entrez Gene 27030
PubMed articles MLH3
OMIM - Gene 604395
OMIM - Diseases AML (leukemia, myeloid, acute (AML))
cancer, gastric (cancer, gastric (neoplasm of stomach))
CRC (cancer, colorectal (CRC))
Lynch Syndrome (cancer, colorectal, nonpolyposis, hereditary, type 1 (Lynch syndrome, HNPCC-1))
MRTES (Muir-Torre Syndrome)
cancer, bladder
cancer, endometrial
cancer, ovarian
cancer, pancreatic
Esophageal cancer

Active transcripts




NCBI ID     

NCBI Protein ID     

00000008 14 mutL homolog 3 (E. coli), transcript variant 1 NM_001040108.1 NP_001035197.1 286

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