Disease #00027

Official abbreviation cancer, gastric
Name cancer, gastric (neoplasm of stomach)
OMIM ID 613659
Human Phenotype Ontology Project (HPO) HPO
Individuals reported having this disease 11
Phenotype entries for this disease 10
Associated with 3 genes MLH3, MSH3, MUTYH
Associated tissues -
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Individuals

11 entries on 1 page. Showing entries 1 - 11.
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00002043 - - - - 32 y died from gastric cancer, CDH1 normal gastric-Ca: MSI-low (1 of 5, D17S250;) IHC predominant loss of PMS2, MLH1, MSH2, MSH6 positive ; second pathology: MSI-high (5 of 10), IHC no clear result obtainable for PMS2 expression - - - cancer, gastric - PMS2 PMS2 1 1 Elke Holinski-Feder
00023520 Marafie et al., 2009 F Kuwait Arab Daughter of patient 2.01;InSiGHT LOVDv2 ID:1011248; Yes AII+ - cancer, gastric cancer, gastric - stomach (7 years) MSH2 MSH2 1 1 Makia Marafie
00023679 - M ES - InSiGHT LOVDv2 ID:12730; - - - cancer, gastric Intestinal type gastric adenocarcinoma poorly differentiated MSH2 MSH2 1 1 Daniel Rueda
00028536 - M UK - - Yes The family history includes colon, endometrial, stomach, bladder and lung cancers with a number of other tumours such as medullablastoma, pituitary tumour and testicular cancer. The only other family member we have been able to test was distant relative (maternal cousin’s daughter) who was diagnosed with endometrial cancer age 44. She also carries the same MSH6 VUS. Testing on endometrial tumour did not show MSI or loss of proteins. - cancer, gastric, CRC adenocarcinoma of the stomach, adenocarcinoma transverse colon age 64 with additional TV adenomas, moderately differentiated adenocarcinoma of splenic flexure MSH2, MSH6, MUTYH MSH6, MUTYH 2 1 John Paul Plazzer
00033624 Vogelaar, submitted - - - 54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type gastric cancer - - - cancer, gastric diffuse-type or intestinal-type gastric cancer - APC 1 1 LOVD_Shared
00033731 Fry, Palmer-Smith, Murray, Frayling, Hodgson, Tripathi M - - Mother and aff'd son have VUS: MLH1 c.790+10A>G, but aff'd father (MSI+ BRAF- CR;Ca 53y) has neither mutation. Maybe father's Rectal;Carcinoma needs IHC and/or his MSH2 sequencing needs looking at in case he is a low level de novo mosaic himself. - Father: Rectal;Carcinoma 53y [MSI-H, BRAF wt; MSH2-, MSH6-, MLH1+, PMS2+] Referred to Genetics by: Surgeon; Referral reason: Self-referral to surgeon after reading BMJ article cancer, gastric, cancer, rectal gastric;carcinoma 50y, rectal;carcinoma - MSH2 1 1 Ian Frayling
00034795 Kim 2004; {OMIM604933:0006} - Korea, South (Republic) - - - - - cancer, gastric in gastric tumor of patient with sporadic gastric cancer, H.pylori +. Not in normal DNA. MUTYH MUTYH 2 1 Carli Tops
00035463 Goto 2008 - Japan - Among 23 Japanese gastric cancer patients - - - cancer, gastric - MUTYH MUTYH 1 1 Astrid Out
00035464 Goto 2008 - Japan - Among 23 Japanese gastric cancer patients - - - cancer, gastric - MUTYH MUTYH 1 7 Astrid Out
00035465 Goto 2008 - Japan - Among 23 Japanese gastric cancer patients - - - cancer, gastric - MUTYH MUTYH 2 5 Astrid Out
00035466 Goto 2008 - Japan - Among 23 Japanese gastric cancer patients - - - cancer, gastric - MUTYH MUTYH 1 12 Astrid Out
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